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dc.contributor.authorKuno, Rubiaes_ES
dc.contributor.authorRoquetti, Maria Helenaes_ES
dc.contributor.authorGouveia, Nelsones_ES
dc.date.accessioned2015-08-25T14:55:59Z
dc.date.available2015-08-25T14:55:59Z
dc.date.issued2010es_ES
dc.identifier.citationKuno, Rubia,Roquetti, Maria Helena,Gouveia, Nelson (2010) Conceitos e derivação de valores de referência para biomonitorização humana de contaminantes ambientais. Rev Panam Salud Publica;27(1) 74-79,jan. 2010. Retrieved from http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892010000100011pt_BR
dc.identifier.urihttp://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892010000100011es_ES
dc.identifier.urihttps://iris.paho.org/handle/10665.2/9576
dc.relation.ispartofseriesRev Panam Salud Publica;27(1),jan. 2010es_ES
dc.subjectPoluição Ambientalpt_BR
dc.subjectExposição Ambientalpt_BR
dc.subjectXenobióticoses_ES
dc.subjectValores de Referênciaes_ES
dc.subjectEnvironmental Pollutiones_ES
dc.subjectEnvironmental Exposurees_ES
dc.subjectXenobioticses_ES
dc.subjectReference valueses_ES
dc.subjectMonitoramento Ambientales_ES
dc.subjectPoluentes Ambientaispt_BR
dc.subjectMarcadores Biológicoses_ES
dc.subjectIntervalos de Confiançaes_ES
dc.subjectGrupos Controlees_ES
dc.subjectExposição Ambientalpt_BR
dc.subjectMonitoramento Ambientales_ES
dc.subjectPoluentes Ambientaispt_BR
dc.subjectProbabilidadees_ES
dc.subjectValores de Referênciaes_ES
dc.subjectAmostragemes_ES
dc.subjectDistribuições Estatísticaspt_BR
dc.subjectXenobióticoses_ES
dc.subjectXenobióticoses_ES
dc.titleConceitos e derivação de valores de referência para biomonitorização humana de contaminantes ambientaispt_BR
dc.typeJournal articlesen_US
dc.rights.holderPan American Health Organizationen_US
dc.description.notesHuman biomonitoring (HBM) of environmental contaminants plays an important role in estimating exposure and evaluating risk, and thus it has been increasingly applied in the environmental field. The results of HBM must be compared with reference values (RV). The term "reference values" has always been related to the interpretation of clinical laboratory tests. For physicians, RV indicate "normal values" or "limits of normal"; in turn, toxicologists prefer the terms "background values" or "baseline values" to refer to the presence of contaminants in biological fluids. This discrepancy leads to the discussion concerning which should be the population selected to determine RV. Whereas clinical chemistry employs an altered health state as the main exclusion criterion to select a reference population (that is, a "healthy" population would be selected), in environmental toxicology the exclusion criterion is the abnormal exposure to xenobiotics. Therefore, the choice of population to determine RV is based on the very purpose of the RV to be determined. The present paper discusses the concepts and methodology used to determine RV for biomarkers of chemical environmental contaminants.(AU)en_US


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