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dc.contributor.authorFranco, Eduardoes_ES
dc.contributor.authorVilla, Luisaes_ES
dc.contributor.authorRohan, Thomases_ES
dc.contributor.authorFerenczy, Alexes_ES
dc.contributor.authorPetzl-Erler, Mariaes_ES
dc.contributor.authorMatlashewski, Greges_ES
dc.date.accessioned2015-08-25T14:54:20Z
dc.date.available2015-08-25T14:54:20Z
dc.date.issued1999es_ES
dc.identifier.citationFranco, Eduardo,Villa, Luisa,Rohan, Thomas,Ferenczy, Alex,Petzl-Erler, Maria,Matlashewski, Greg (1999) Design and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazil. Rev Panam Salud Publica;6(4) -,oct. 1999. Retrieved from http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49891999000900001&lng=pt&nrm=isoen_US
dc.identifier.urihttp://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49891999000900001&lng=pt&nrm=isoes_ES
dc.identifier.urihttps://iris.paho.org/handle/10665.2/8864
dc.format.extenttabes_ES
dc.relation.ispartofseriesRev Panam Salud Publica;6(4),oct. 1999es_ES
dc.subjectPapilomaes_ES
dc.subjectNeoplasia Intraepitelial Cervicales_ES
dc.subjectEstudos de Coortespt_BR
dc.subjectEstudos Longitudinaispt_BR
dc.subjectBrasilpt_BR
dc.titleDesign and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazilen_US
dc.typeJournal articlesen_US
dc.rights.holderPan American Health Organizationen_US
dc.description.notesThis article reports on a large longitudinal study, begun in 1993, of the natural history of human papillomavirus (HPV) infection and cervical neoplasia in a population of low-income women in Sao Paulo, Brazil, a city with one of the highest risks worldwide for cervical cancer. Known as the Ludwig-McGill cohort study, the epidemiological investigation focuses on persistent infection with oncogenic HPV types as the precursor event leading to cervical neoplasia. The objectives of this study are to: 1) study the epidemiology of persistent cervical HPV infection in asymptomatic women, 2) investigate whether persistent HPV infection increases risk of low-grade and high-grade cervical lesions, 3) search for determinants of persistent HPV infection, 4) search for molecular variants of HPV that may be associated with an increased risk of lesions, 5) investigate whether viral burden is correlated with persistent infections and with lesion risk, 6) study the antibody response to HPV as a predictor of persistence and lesion progression, and 7) examine the role of HLA typing and codon 72 p53 gene polymorphism in mediating HPV persistence and lesion severity. The study accrued 2.528 female subjects through March 1997. Subjects were followed up every 4 months in the first year, with twice-yearly return visits to take place in subsequent years. Participants undergo a questionnaire-based interview, have a cervical specimen taken for Pap cytology and HPV testing, and have a blood sample drawn for HPV antibody testing. A cervicography is performed once in the first year and every two years thereafter. In this article we describe the design and methods of the study, provide baseline cohort characteristics, and present a preliminary assessment of the prognostic value of baseline HPV statusen_US


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