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Evaluation of the concomitant use of two different EIA tests for HIV screening in blood banks

dc.contributor.authorOtani, Marcia Mes_ES
dc.contributor.authorSalles, Nanci Aes_ES
dc.contributor.authorBarreto, Angela M. Ees_ES
dc.contributor.authorBarreto, Claudia Ces_ES
dc.contributor.authorChamone, Dalton Fes_ES
dc.contributor.authorSabino, Ester Ces_ES
dc.date.accessioned2015
dc.date.available2015
dc.date.issued2003es_ES
dc.identifier.citationOtani, Marcia M,Salles, Nanci A,Barreto, Angela M. E,Barreto, Claudia C,Chamone, Dalton F,Sabino, Ester C (2003) Evaluation of the concomitant use of two different EIA tests for HIV screening in blood banks. Rev Panam Salud Publica;13(2/3) 172-175,feb.-mar. 2003. Retrieved from http://www.scielosp.org/pdf/rpsp/v13n2-3/15735.pdfen_US
dc.identifier.urihttp://www.scielosp.org/pdf/rpsp/v13n2-3/15735.pdfes_ES
dc.identifier.urihttps://iris.paho.org/handle/10665.2/8394
dc.format.extenttabes_ES
dc.relation.ispartofseriesRev Panam Salud Publica;13(2/3),feb.-mar. 2003es_ES
dc.subjectSorodiagnóstico da AIDSes_ES
dc.subjectBancos de Sanguees_ES
dc.subjectSoropositividade para HIVpt_BR
dc.subjectProgramas de Rastreamentoes_ES
dc.subjectSorodiagnóstico da AIDSes_ES
dc.subjectBancos de Sanguees_ES
dc.subjectDoadores de Sanguees_ES
dc.subjectBrasilpt_BR
dc.subjectSoropositividade para HIVpt_BR
dc.subjectTécnicas Imunoenzimáticases_ES
dc.subjectTécnicas Imunoenzimáticases_ES
dc.subjectProgramas Obrigatórioses_ES
dc.subjectProgramas de Rastreamentoes_ES
dc.subjectAvaliação de Programas e Projetos de Saúdept_BR
dc.subjectControle de Qualidadees_ES
dc.titleEvaluation of the concomitant use of two different EIA tests for HIV screening in blood banksen_US
dc.typeJournal articlesen_US
dc.rights.holderPan American Health Organizationen_US
dc.description.notesOBJECTIVE: In 1998, the Brazilian Ministry of Health made it mandatory for all blood banks in the country to screen donated blood for human immunodeficiency virus (HIV) concomitantly using two different enzyme immunoassay (EIA) tests. Concerned with the best use of available resources, our objective with this study was to evaluate the usefulness of conducting two EIA screening tests instead of just one. METHODS: We analyzed data from 1999 through 2001 obtained by testing 698 191 units of donated blood using two EIA HIV screening tests concomitantly at the Pro-Blood Foundation/Blood Center of Säo Paulo (Fundaçäo Pró-Sangue/Hemocentro de Säo Paulo), which is a major blood center in the city of Säo Paulo, Brazil. All samples reactive in at least one of the two EIA tests were submitted for confirmation by a Western blot (WB) test, and the persons who had donated those samples were also asked to return and provide a follow-up sample. RESULTS: Out of the 698 191 blood units that were donated, 2 718 of them (0.4 percent) had to be discarded because they were reactive to at least one of the EIA tests. There were two WB-positive donation samples that were reactive in only one HIV EIA screening test. On their follow-up samples, both donors tested WB-negative. These cases were considered false positive results at screening. Of the 2 718 donors who were asked to return and provide a follow-up sample, 1 576 of them (58 percent) did so. From these 1 576 persons, we found that there were two individuals who had been reactive to only one of the two EIA screening tests and who had also been negative on the WB at screening but who were fully seroconverted on the follow-up sample. We thus estimated that, in comparison to the use of a single EIA screening test, the use of two EIA screening tests would detect only one extra sample out of 410 700 units of blood. CONCLUSIONS: Our data do not support the use of two different, concomitant EIA screening tests for HIV. The great majority of HIV-positive donors have already seroconverted and will be detected using only a single EIA screening test. Only persons who are going through the process of seroconversion may be missed by using a single EIA test and detected using two EIAs for screening. To screen out these individuals and decrease the residual risk of HIV transmission from the blood donated in our center, the use of other techniques, such as nucleic acid testing (NAT) or a p24 antigen assay, would be more effective (AU)pt_BR


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