View Item 

Show simple item record

Meningitis and pneumonia in Guatemalan children: the importance of Haemophilus influenzae type b and Streptococcus pneumoniae

dc.contributor.authorAsturias, Edwin Jes_ES
dc.contributor.authorSoto, Monicaes_ES
dc.contributor.authorMenendez, Ricardoes_ES
dc.contributor.authorRamirez, Patricia Les_ES
dc.contributor.authorRecinos, Fabioes_ES
dc.contributor.authorGordillo, Remeies_ES
dc.contributor.authorHolt, Elizabethes_ES
dc.contributor.authorHalsey, Neal Aes_ES
dc.date.accessioned2015
dc.date.available2015
dc.date.issued2003es_ES
dc.identifier.citationAsturias, Edwin J,Soto, Monica,Menendez, Ricardo,Ramirez, Patricia L,Recinos, Fabio,Gordillo, Remei,Holt, Elizabeth,Halsey, Neal A (2003) Meningitis and pneumonia in Guatemalan children: the importance of Haemophilus influenzae type b and Streptococcus pneumoniae. Rev Panam Salud Publica;14(6) 377-384,dic. 2003. Retrieved from http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892003001100002en_US
dc.identifier.urihttp://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892003001100002es_ES
dc.identifier.urihttps://iris.paho.org/handle/10665.2/8301
dc.format.extenttabes_ES
dc.format.extentgrafes_ES
dc.relation.ispartofseriesRev Panam Salud Publica;14(6),dic. 2003es_ES
dc.subjectMeningite por Haemophiluses_ES
dc.subjectPneumonia Pneumocócicaes_ES
dc.subjectGuatemalaes_ES
dc.subjectHaemophilus Influenzaees_ES
dc.subjectHospitalizaçãopt_BR
dc.subjectIncidênciapt_BR
dc.subjectMeningite por Haemophiluses_ES
dc.subjectPneumonia Pneumocócicaes_ES
dc.subjectSepsees_ES
dc.subjectStreptococcus pneumoniaees_ES
dc.titleMeningitis and pneumonia in Guatemalan children: the importance of Haemophilus influenzae type b and Streptococcus pneumoniaeen_US
dc.typeJournal articlesen_US
dc.rights.holderPan American Health Organizationen_US
dc.description.notesOBJECTIVE: To determine the epidemiology of Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae invasive infections in hospitalized Guatemalan children. This is an important issue since Hib vaccine has not been incorporated into the routine immunization program in Guatemala and information from hospital records in 1995 indicated a low incidence of Hib and S. pneumoniae as causes of meningitis and invasive infections. METHODS: Children who were hospitalized in Guatemala City with clinical signs compatible with bacterial infections were evaluated for evidence of Hib or S. pneumoniae infection. Normally sterile body fluids were cultured, and antigen detection was performed on cerebrospinal fluid (CSF) and pleural fluid. RESULTS: Of 1 203 children 1-59 months of age hospitalized over a 28-month period, 725 of them (60.3 percent) had a primary diagnosis of pneumonia, 357 (29.7 percent) of meningitis, 60 (5.0 percent) of cellulitis, and 61 (5.1 percent) of sepsis and other conditions. Hib was identified in 20.0 percent of children with meningitis and S. pneumoniae in 12.9 percent. The average annual incidence of Hib meningitis was 13.8 cases per 100 000 children under 5 years of age, and 32.4 percent of meningitides caused by Hib and 58.7 percent of S. pneumoniae meningitides occurred prior to 6 months of age. Case fatality rates were 14.1 percent, 37.0 percent, and 18.0 percent, respectively, for children with Hib, S. pneumoniae, and culture-negative and antigen-negative meningitis. Prior antibiotic therapy was common and was associated with significant reductions in CSF-culture-positive results for children with other evidence of Hib or S. pneumoniae meningitis. CONCLUSIONS: Improvements in case detection, culture methods, and latex agglutination for antigen detection in CSF resulted in identification of Hib and S. pneumoniae as important causes of severe disease in Guatemalan children. Using a cutoff of 10 white blood cells per cubic millimeter in CSF would improve the sensitivity for detection of bacterial meningitis and help estimate the burden of bacterial meningitis in Guatemala and other developing countries.(AU)en_US


Files in this item

Thumbnail
Name:
a02v14n6.pdf
Size:
100.9Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record