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Assessing HIV resistance in developing countries: Brazil as a case study

dc.contributor.authorPetersen, Maya Les_ES
dc.contributor.authorBoily, Marie-Claudees_ES
dc.contributor.authorBastos, Francisco Ies_ES
dc.date.accessioned2015
dc.date.available2015
dc.date.issued2006es_ES
dc.identifier.citationPetersen, Maya L,Boily, Marie-Claude,Bastos, Francisco I (2006) Assessing HIV resistance in developing countries: Brazil as a case study. Rev Panam Salud Publica;19(3) 146-156,mar. 2006. Retrieved from http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892006000300002es_ES
dc.identifier.urihttp://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892006000300002es_ES
dc.identifier.urihttps://iris.paho.org/handle/10665.2/7991
dc.format.extenttabes_ES
dc.relation.ispartofseriesRev Panam Salud Publica;19(3),mar. 2006es_ES
dc.subjectAntirretroviraises_ES
dc.subjectHIVes_ES
dc.subjectInfecções por HIVpt_BR
dc.subjectTerapia Antirretroviral de Alta Atividadees_ES
dc.subjectBrasilpt_BR
dc.subjectFarmacorresistência Virales_ES
dc.subjectHIVes_ES
dc.subjectInfecções por HIVpt_BR
dc.subjectInfecções por HIVpt_BR
dc.subjectInfecções por HIVpt_BR
dc.subjectPrevalênciapt_BR
dc.subjectAssunção de Riscospt_BR
dc.titleAssessing HIV resistance in developing countries: Brazil as a case studyes_ES
dc.typeJournal articlesen_US
dc.rights.holderPan American Health Organizationen_US
dc.description.notesIncreased transmission of resistant HIV has been raised as a potential consequence of expanded access to antiretroviral therapy. We review how limitations in resources and health care infrastructure may impact the transmission of resistant HIV, and we examine data from Brazil as a case study. We introduce a biological and clinical framework to identify the major determinants of transmitted resistance and to discuss how these determinants may be affected by a lack of infrastructure. We then use our framework to examine HIV resistance data from Brazil. This country was chosen as a case study due to its extensive experience delivering antiretroviral drugs and because of the availability of data on the prevalence of resistant HIV there. The data from Brazil show that antiretroviral therapy can be delivered in a resource-limited setting without resulting in widespread transmission of resistant virus. While the Brazilian experience does not necessarily generalize to countries with less health care infrastructure, neither theory nor data support a foregone conclusion that resistance will necessarily dominate HIV epidemics in the developing world to a greater extent than it does in the developed world. (AU)en_US


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