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Assessing HIV resistance in developing countries: Brazil as a case study

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Date
2006
Author
Petersen, Maya L
Boily, Marie-Claude
Bastos, Francisco I
Metadata
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Abstract
Increased transmission of resistant HIV has been raised as a potential consequence of expanded access to antiretroviral therapy. We review how limitations in resources and health care infrastructure may impact the transmission of resistant HIV, and we examine data from Brazil as a case study. We introduce a biological and clinical framework to identify the major determinants of transmitted resistance and to discuss how these determinants may be affected by a lack of infrastructure. We then use our framework to examine HIV resistance data from Brazil. This country was chosen as a case study due to its extensive experience delivering antiretroviral drugs and because of the availability of data on the prevalence of resistant HIV there. The data from Brazil show that antiretroviral therapy can be delivered in a resource-limited setting without resulting in widespread transmission of resistant virus. While the Brazilian experience does not necessarily generalize to countries with less health care infrastructure, neither theory nor data support a foregone conclusion that resistance will necessarily dominate HIV epidemics in the developing world to a greater extent than it does in the developed world. (AU)
Series
Rev Panam Salud Publica;19(3),mar. 2006
Subject
Antirretrovirais; HIV; Infecções por HIV; Terapia Antirretroviral de Alta Atividade; Brasil; Farmacorresistência Viral; HIV; Infecções por HIV; Infecções por HIV; Infecções por HIV; Prevalência; Assunção de Riscos
URI
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892006000300002
https://iris.paho.org/handle/10665.2/7991
Citation
Petersen, Maya L,Boily, Marie-Claude,Bastos, Francisco I (2006) Assessing HIV resistance in developing countries: Brazil as a case study. Rev Panam Salud Publica;19(3) 146-156,mar. 2006. Retrieved from http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892006000300002
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  • Pan American Journal of Public Health

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