Living Systematic Review of Therapeutic Options for Post COVID-19 Condition, 11 January 2023

Abstract

Post COVID-19 condition (PCC), also known as long COVID or post-acute sequelae of SARS-CoV-2 infection (PASC), is the continuation or development of new symptoms in the period after acute infection with SARS-CoV-2. PCC can affect anyone exposed to SARS-CoV-2, regardless of age or the severity of the acute infection. Many of the reported symptoms are debilitating and have a strong negative impact on mental health and the quality of life. While most patients recover, some may experience multiple outcomes, with multiple organ systems affected simultaneously, including the cardiovascular, mental, metabolic, renal, and other systems.

This publication of the Pan American Health Organization is a living systematic review that compiles the current evidence on potential therapeutic options for PCC. It includes all the identified clinical forms, symptoms, and manifestations of PCC for which an intervention was assessed in at least one randomized controlled trial. It is hoped this information will support investigators, policymakers, and prescribers navigate the flood of relevant data to ensure that management of PCC, at both the individual and population levels, is based on the best available knowledge. As a living document, this resource will be continually updated as more research is released into the public space.