Regulatory considerations on authorization of the use of convalescent plasma (PC) to address the COVID-19 emergency, 22 April 2020
MetadataShow full item record
Since the last century, passive immunization has been used for the prevention and treatment of some human infectious diseases. The serum of convalescent patients is the treatment of choice in cases of Argentine Hemorrhagic Fever. In addition, it was use during outbreaks of Ebola in Africa and also during the SARS and MERS outbreaks, as no other therapeutic options existed. Experience to date with the use of convalescent plasma for the treatment of COVID-19 is limited, but preliminary results indicate potential usefulness. Several controlled clinical trials are underway, to collect more quality scientific evidence to confirm the safety and efficacy of this intervention. In this context, the recommendations foresee its use under experimental conditions within the regulatory framework of each country. Moreover, there are challenges for large-scale collection, processing, and distribution of plasma from convalescent patients to meet potential clinical needs. Some published guidance exists for the collection and use of plasma from convalescent patients in infectious disease cases and Ebola outbreaks and even in the current COVID-19 situation.
This notice should be preserved along with the article's original URL.Attribution-NonCommercial-ShareAlike 3.0 IGO
Showing items related by title, author, creator and subject.
Safety of COVID-19 Patients and Use of Medicines without Scientific Evidence of Their Benefit, 26 May 2020 Pan American Health Organization; Evidence and Intelligence for Action in Health (EIH) (Washington, D.C., PAHO, 2020-05-26)COVID-19 treatment options currently under study include several antiviral drugs and immune modulators, the antimalarials chloroquine and hydroxychloroquine, corticosteroids, convalescent plasma, pharmaceutical products ...
Ongoing Living Update of Potential COVID-19 Therapeutics: summary of rapid systematic reviews. Rapid Review, 23 May 2020 Pan American Health Organization; Evidence and Intelligence for Action in Health (EIH) (Washington, D.C., PAHO, 2020-05-23)This document includes the results of a rapid systematic review of currently available literature. The information included in this review reflects the evidence as of the date posted in the document. Yet, recognizing that ...
Recommendations for medical surge capacity and deployment of emergency medical teams. Preliminary Document, Version 2 (31 March 2020) Pan American Health Organization; Health Emergencies (PHE) (Washington, D.C., PAHO, 2020-03-31)The purpose of this document is to issue recommendations to facilitate the medical surge capacity and the deployment of emergency medical teams in order to guarantee the response to high numbers of patients that could ...