Foot-and-Mouth disease vaccines. I. Comparison of vaccines prepared from virus inactivated with formalin and adsorbed on aluminum hydroxide gel with saponin and virus inactivated with acetylethyleneimine and emulsified with incomplete Freund’s adjuvant

Abstract

[Introduction] A series of cooperative studies by PIADC and the Pan American Foot-and-Mouth Disease Center (PAFMDC) was undertaken in the isolation units at PAFMDC in Rio de Janeiro in an effort to determine the value of such vacines for the future field experiments in South America. Brazilian cattle, pigs and sheep were vaccinated with conventional formaldehyde-inactivated aluminum hydroxide gel-saponin adjuvanted FMD vaccines or with vaccines inactivated with AEI and emulsified with incomplete Freund’s adjuvant. Antibody development and the degree of immunity of the animals at various times after vaccination and revaccination with two vaccines were compared.