The effect of merthiolate on the inmunogenicity of foot-and-mouth disease virus antigens
Date
1977ISSN
0009-0131
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Merthiolate is commonly used as a preservative in commercial inactivated foot-and-mouth disease (FMD) vaccines. However, experiments with inactivated poliomyelitis vaccines have shown that degradation products of merthiolate can affect the virus antigen during storage of the vaccine (1). The effect of merthiolate can be neutralized by treatment with EDTA (trisodium salt of ethylene diamine tetra-acetic acid). Precipitation reactions in agar gel with FMD virus also show deleterious effects of merthiolate (2).
Citation
Abaracón D. The effect of merthiolate on the inmunogenicity of foot-and-mouth disease virus antigens. Bol Cent Panam Fiebre Aftosa. 1977; 26: 47-48.
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