• español
    • English
    • português
  • English 
    • español
    • English
    • português
  • IRIS PAHO Home
  • PAHO website
  • Indexes
  • All Collections
  • About IRIS
  • Institutional Memory
  • Our Newsletter
  • Contact
JavaScript is disabled for your browser. Some features of this site may not work without it.
View Item 
  •   IRIS PAHO Home
  • 1.PAHO Headquarters / Sede de la OPS
  • Scientific Journals and Newsletters / Revistas Científicas y Boletines
  • Pan American Journal of Public Health
  • View Item
  •   IRIS PAHO Home
  • 1.PAHO Headquarters / Sede de la OPS
  • Scientific Journals and Newsletters / Revistas Científicas y Boletines
  • Pan American Journal of Public Health
  • View Item

Evaluation of three commercially-available chikungunya virus immunoglobulin G immunoassays

Thumbnail
View/Open
v41a622017.pdf (961.5Kb)
Date
2017-06
Author
De Salazar, Pablo M.
Valadere, Anne Marie
Goodman, Christin H.
Johnson, Barbara W.
Type of paper
Brief communications
Metadata
Show full item record

Abstract
The emergence of chikungunya virus in the Americas means the affected population is at risk of developing severe, chronic, rheumatologic disease, even months after acute infection. Accurate diagnostic methods for past infections are essential for differential diagnosis and consequence management. This study evaluated three commercially-available chikungunya Immunoglobulin G immunoassays by comparing them to an in-house Enzyme-Linked ImmunoSorbent Assay conducted by the Centers for Disease Control and Prevention (Atlanta, Georgia, United States). Results showed sensitivity and specificity values ranging from 92.8% – 100% and 81.8% – 90.9%, respectively, with a significant number of false-positives ranging from 12.5% – 22%. These findings demonstrate the importance of evaluating commercial kits, especially regarding emerging infectious diseases whose medium and long-term impact on the population is unclear.
 
Como consecuencia de la aparición del virus del chikungunya en las Américas, la población afectada corre el riesgo de padecer reumatismos crónicos graves, aun meses después de la infección aguda. Es fundamental contar con métodos precisos para diagnosticar los antecedentes de la infección a fin de elaborar un diagnóstico diferencial y abordar las manifestaciones de la fase crónica. Se han estudiado tres inmunoensayos comercializados de detección de inmunoglobulinas G para el diagnóstico del chikungunya, comparándolos con el enzimoinmunoanálisis de adsorción (ELISA) propio. Los resultados señalan valores de sensibilidad del 92,8% al 100% y de especificidad del 81,8% al 90,9%, así como un número significativo de falsos positivos, de entre el 12,5% y el 22%.
 
Translated title
Evaluación de tres inmunoensayos comercializados de inmunoglobulina G para el diagnóstico del virus del chikungunya
Series
Rev Panam Salud Publica;41, jun. 2017
Subject
Chikungunya virus; Reagent Kits, Diagnostic; Immunoassay; Immunoenzyme Techniques; Fluorescence Polarization Immunoassay; Caribbean Region; Americas; Virus Chikungunya; Juego de Reactivos para Diagnóstico; Inmunoensayo; Técnicas para Inmunoenzimas; Inmunoensayo de Polarización Fluorescente
Category of PAHO Strategic Plan 2014-2019
Cat 1. Communicable Diseases
URI
https://iris.paho.org/handle/10665.2/34100
Citation
De Salazar PM, Valadere A, Goodman CH, Johnson BW. Evaluation of three commercially-available chikungunya virus immunoglobulin G immunoassays. Rev Panam Salud Publica. 2017; 41:e62.
Collections
  • Pan American Journal of Public Health

Related items

Showing items related by title, author, creator and subject.

  • Thumbnail

    Prolonged Zika virus viremia in a patient with Guillain-Barré syndrome in Trinidad and Tobago 

    Gonzalez-Escobar, Gabriel; Valadere, Anne Marie; Adams, Rosmond; Polson-Edwards, Karen; Hinds, Avery Q.J.; Misir, Akenath; Hospedales, C. James (2017-09)
    An emerging mosquito-borne flavivirus, Zika virus (ZIKV) is a significant public health concern because of the syndromes associated with the infection. In addition, ZIKV is considered a major problem due to large-scale ...
  • Thumbnail

    Development of in-house serological methods for diagnosis and surveillance of chikungunya 

    Saborío Galo, Saira; González, Karla; Téllez, Yolanda; García, Nadezna; Pérez, Leonel; Gresh, Lionel; Harris, Eva; Balmaseda, Ángel (2017-06)
    Objective. To develop and evaluate serological methods for chikungunya diagnosis and research in Nicaragua. Methods. Two IgM ELISA capture systems (MAC-ELISA) for diagnosis of acute chikungunya virus (CHIKV) infections, ...
  • Thumbnail

    Epidemiological characteristics of a Zika outbreak in Portoviejo, Ecuador, 2016 

    Fors, Martha; Silva, Eduardo; González, Paloma (2018-05)
    [ABSTRACT]. Objective. To estimate the number and percentage of cases with Zika diagnosis at a hospital in Portoviejo, Manabí, Ecuador. Methods. This was a hospital-based, retrospective, observational, descriptive, ...

Browse

All of IRIS PAHOCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsSeries TitleType of materialLanguageCategoryThis CollectionBy Issue DateAuthorsTitlesSubjectsSeries TitleType of materialLanguageCategory

Statistics

View Usage Statistics

Pan American Health Organization
World Health Organization. Regional Office for the Americas
525 Twenty-third Street, N.W., Washington, D.C. 20037, United States of America
Tel.: +1 (202) 974-3000 Fax: +1 (202) 974-3663
email: libraryhq@paho.org

Links

  • PAHO Featured Publications
  • WHO Digital Library (IRIS)
  • Virtual Health Library (VHL)
  • Global Index Medicus (GIM)