Minimum infectious dose for chikungunya virus in Aedes aegypti and Ae. albopictus mosquitoes
Date
2017-06Metadata
Show full item recordAbstract
Understanding the ability of the chikungunya virus (CHIKV) to be transmitted by Aedes
vectors in the Americas is critical for assessing epidemiological risk. One element that must
be considered is the minimum infectious dose of virus that can lead to transmission following
the extrinsic incubation period. This study aimed to determine the minimum infection rate
for the two Aedes species studied. The results revealed that doses as low as 3.9 log10 plaqueforming
units per mL (pfu/mL) of an Asian genotype CHIKV strain can lead to transmission
by Ae. albopictus, and doses of at least 5.3 log10 pfu/mL from the same strain are needed for
transmission from Ae. aegypti. These low infecting doses suggest that infected individuals
may be infectious for almost the entire period of their viremia, and therefore, to prevent further
cases, measures should be taken to prevent them from getting bitten by mosquitoes
during this period. Comprender la capacidad del virus del chikungunya (CHIKV) de ser transmitido por
los vectores del género Aedes en la Región de las Américas es fundamental para
evaluar
el riesgo epidemiológico. Un elemento que debe tenerse en cuenta es la dosis
infecciosa mínima de virus que posibilita la transmisión después del período de incubación
extrínseco. El objetivo de este estudio ha sido determinar la tasa de infección
mínima para las dos especies del género Aedes estudiadas. Los resultados indican
que bastan dosis de tan solo 3,9 log10 unidades formadoras de placas por mililitro
(ufp/ml) de una cepa de CHIKV del genotipo asiático para que se produzca la transmisión
por Ae. albopictus, en tanto que para la transmisión por Ae. aegypti se necesitan
dosis de al menos 5,3 log10 ufp/ml de la misma cepa. Estas dosis bajas indican que
las personas infectadas podrían conservar el potencial infeccioso prácticamente
durante todo el período de viremia y, por consiguiente, a fin de prevenir más casos,
habría que tomar medidas para impedir que reciban picaduras de mosquitos durante
ese período.
Translated title
Dosis infecciosa mínima del virus del chikungunya en los mosquitos Aedes aegypti y Ae. albopictus
Subject
Category of PAHO Strategic Plan 2014-2019
Citation
Ledermann JP, Borland EM, Powers AM. Minimum infectious dose for chikungunya virus in Aedes aegypti and Ae. albopictus mosquitoes. Rev Panam Salud Publica. 2017;41:e65.
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