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Protective efficacy of BCG against leprosy in Sao Paulo

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Date
1996
Author
Lombardi, Clovis
Silva Pedrazzani, Elisete
Pedrazzani, Joao Carlos
Ferreira Filho, Pedro
Zicker, Fabio
Metadata
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Abstract
The case-control study reported here evaluated the protective effect of BCG vacine against leprosy in Sao Paulo, Brazil. Seventy-eight patients under age 16 who had been diagnosed as having leprosy (cases) and 385 healthy individuals (controls) were selected and matched by sex, age, place of residence, and type of exposure to leprosy (intradomiciliary or extradomiciliary). The cases were draw from an active patient registry and from a group of new leprosy cases treated at 50 health centers in the cities of Bauru and Ribeirao Preto in the state of Sao Paulo. In order to estimate the protective effect of BCG, the prevalences of BCG scars in cases and controls were compared. The presence of one or more scars was associated with an estimated protective efficacy of 90 percent (95 percent confidence interval: 78 percent to 96 percent). Stratified analysis by age group, sex, socieconomic level, and clinical form of the disease revealed no significant differences in the protection provided by the vaccine, However, it seems clear that more data will be needed in order to accurately assess the true relevance of BCG for leprosy control programs (AU)
 
This article was also published in Spanish in the Bol. Ofic. Sanit. Panam. Vol. 119(5):415-22, 1995
 
Series
Bulletin of the Pan American Health Organization (PAHO);30(1),mar. 1996
Subject
BCG Vaccine; Leprosy; Case-Control Studies; Brazil
URI
https://iris.paho.org/handle/10665.2/27760
Collections
  • Pan American Journal of Public Health

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