• español
    • English
    • português
  • English 
    • español
    • English
    • português
  • IRIS PAHO Home
  • PAHO website
  • Indexes
  • All Collections
  • About IRIS
  • Institutional Memory
  • Our Newsletter
  • Contact
JavaScript is disabled for your browser. Some features of this site may not work without it.
View Item 
  •   IRIS PAHO Home
  • 1.PAHO Headquarters / Sede de la OPS
  • Scientific Journals and Newsletters / Revistas Científicas y Boletines
  • Pan American Journal of Public Health
  • View Item
  •   IRIS PAHO Home
  • 1.PAHO Headquarters / Sede de la OPS
  • Scientific Journals and Newsletters / Revistas Científicas y Boletines
  • Pan American Journal of Public Health
  • View Item

Influenza: its antigenic variation and ecology

Thumbnail
View/Open
ev10n3p193.pdf (208.3Kb)

Date
1976
Author
Dowdle, Walter Reid
Schild, G.C
Metadata
Show full item record
Abstract
Influenza viruses have two surface antigens, the glycoprotein structures hemagglutinin (HA) and neuraminidase (NA). Antibodies to each of these are associated with immunity, but the structures themselves are antigenically variable. When an antigenic change is gradual over time it is referred to as a drift, while a sudden complete or major change in either or both antigens is termed a shift. The mechanism of antigenic drift is usually attributed to selection of preexisting mutants by pressure from increasing immunity in the human population. The mechanism of antigenic shift is less clear, but one tentative hypothesis is that shifts arise from mammalian or avian reservoirs, or through genetic recombination of human and animal influenza strains (Au)
Series
Bulletin of the Pan American Health Organization (PAHO);10(3),1976
Subject
Antigens, Viral; Orthomyxoviridae
URI
https://iris.paho.org/handle/10665.2/27655
Collections
  • Pan American Journal of Public Health

Related items

Showing items related by title, author, creator and subject.

  • Thumbnail

    Epidemiological Alert, 2003-2004 Flu Season in North America, Circulation of Human Metapneumovirus in the United States; Call for Abstracts, International Conference of Emerging Infectious Diseases, Atlanta 2004: Deadline Extended (4 December 2003) 

    Pan American Health Organization; Health Emergencies (PHE) (Washington, D.C., PAHO, 2003-12-04)
    In 2003-2004 season an increased influenza activity has been detected earlier than in previous seasons. The predominant virus circulating in North America is similar to A/ Fujian/411/2002. In the USA CDC has antigenically ...
  • Thumbnail

    Naturaleza y variación de los antígenos parasitarios 

    Brown, K. N (s.d.)
    In any experimental approach many factors will have to be considered and each parasite will set its own technical limitations. Nevertheless the points mentioned in this article are likely to contribute to a full analysis ...
  • Thumbnail

    The prevalence of hepatitis B antigen among hepatitis patients and residents of Peru 

    Madalengoitia, José; Ishida, N; Umenay, T; Miyamoto, T; Mejía, J; Flores, William; Sánchez, S; Méndez, R (1975)
    Single radial immune diffusion and counterelectrophoresis tests were used to examine 2,593 serum speciments from apparently healthy men, women, and children of Peru for the presence of hepatitis B antigen (Australia antigen). ...

Browse

All of IRIS PAHOCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsSeries TitleType of materialLanguageCategoryTechnical Unit/Country OfficeThis CollectionBy Issue DateAuthorsTitlesSubjectsSeries TitleType of materialLanguageCategoryTechnical Unit/Country Office

Statistics

View Usage Statistics

Pan American Health Organization
World Health Organization. Regional Office for the Americas
525 Twenty-third Street, N.W., Washington, D.C. 20037, United States of America
Tel.: +1 (202) 974-3000 Fax: +1 (202) 974-3663
email: libraryhq@paho.org

Links

  • PAHO Featured Publications
  • WHO Digital Library (IRIS)
  • Virtual Health Library (VHL)
  • Global Index Medicus (GIM)