Estudios sobre la infeccion de ratones endogamicos con clones de Trypanosoma cruzi

Abstract

The project, which is ongoing, consists of infecting strains of inbred mice with stocks of single-cell-isolated clones of Trypanosoma cruzi and studying the course and outcome of these infections. Research procedures included the determination of the following aspects: 1) virulence spectrum of T. cruzi clones; 2) mouse strain-dependent susceptibility to infection with T. cruzi clones; 3) effect of the number of parasites inoculated on the outcome of infection with T. cruzi clones; 4) influence of the route of inoculation on the outcome of infection; 5) influence of the handling of the parasite on the outcome of infection; 6) influence of the infection by one T. cruzi clone upon the outcome of infection by a second clone, and 7) a multiparametric, time series analysis of the course of infection in a large group of mice for the development of a chronic Chagas' disease model