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dc.contributor.authorDíaz, Ana Maria O. dees_ES
dc.contributor.authorDellepiane, Noraes_ES
dc.contributor.authorPalomo, Luis Fes_ES
dc.date.accessioned2015
dc.date.available2015
dc.date.issueds.d.es_ES
dc.date.issued1989es_ES
dc.identifier.urihttps://iris.paho.org/handle/10665.2/17696
dc.description.abstractSuckling mouse brain (SMB) rabies vaccine is the preparation most widely used in the countries of Latin America and the Caribbeanen_US
dc.description.abstractThis vaccine, prepared according to the Fuenzalida and Palacios method, consists of three fixed rabies virus strains (CVS, 51, and 91). However, the World Health Organization recommends that rabies vaccines for human use be prepared using only a single strain of this virusen_US
dc.description.abstractIn order to determine whether any one of the antigens of the SMB vaccine could be eliminated from the preparation, the immunogenic capacity of the standard trivalent SMB vaccine was compared with that of experimental bivalent (CVS-51, CVS-91, and 51-91) and monovalent (CVS, 51, and 91) SMB vaccinesen_US
dc.description.abstractThe study was conducted using adult and suckling albino mice provided by the laboratory at the Pan American Zoonoses Center, Buenos Aires, Argentina, and different strains of fixed and street rabies virusen_US
dc.description.abstractThe experimental vaccines were prepared using the Fuenzalida-Palacios methodes_ES
dc.description.abstractPotency and cross-immunity tests were conducteden_US
dc.description.abstractThe result showed that the trivalent vaccine was the most effective in protecting the mice againg both fixed and street rabies virus infections and also in inducing rapid development of neutralizing antibody at high titersen_US
dc.format.extentgrafes_ES
dc.relation.ispartofseriesBoletín de la Oficina Sanitaria Panamericana (OSP);107(3),sept. 1989es_ES
dc.subjectVacinas Antirrábicaspt_BR
dc.subjectVacinas Antirrábicaspt_BR
dc.subjectVírus da Raivaes_ES
dc.subjectAmérica Latinaes_ES
dc.subjectRegião do Caribept_BR
dc.titleVacuna antirrábica de cerebro de ratón lactante: Composición antigénica y capacidad inmunógenaes_ES
dc.title.alternativeSuckling mouse brain rabies vaccine: Antigenic composition and immunogenic capacityen_US
dc.typeJournal articlesen_US
dc.rights.holderPan American Health Organizationen_US


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