Vacuna antirrábica de cerebro de ratón lactante: Composición antigénica y capacidad inmunógena
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Suckling mouse brain (SMB) rabies vaccine is the preparation most widely used in the countries of Latin America and the CaribbeanThis vaccine, prepared according to the Fuenzalida and Palacios method, consists of three fixed rabies virus strains (CVS, 51, and 91). However, the World Health Organization recommends that rabies vaccines for human use be prepared using only a single strain of this virusIn order to determine whether any one of the antigens of the SMB vaccine could be eliminated from the preparation, the immunogenic capacity of the standard trivalent SMB vaccine was compared with that of experimental bivalent (CVS-51, CVS-91, and 51-91) and monovalent (CVS, 51, and 91) SMB vaccinesThe study was conducted using adult and suckling albino mice provided by the laboratory at the Pan American Zoonoses Center, Buenos Aires, Argentina, and different strains of fixed and street rabies virusThe experimental vaccines were prepared using the Fuenzalida-Palacios methodPotency and cross-immunity tests were conductedThe result showed that the trivalent vaccine was the most effective in protecting the mice againg both fixed and street rabies virus infections and also in inducing rapid development of neutralizing antibody at high titers
Suckling mouse brain rabies vaccine: Antigenic composition and immunogenic capacity
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Koprowski, Hilary (s.d.)Currently available antirabies vaccines prepared from either animal brains or embryonated eggs have the unavoidable disadvantage of products prepared in vivo; the bulk of antigenic material in the vaccine is not viral but ...
Para, Madureira; Passos, Waldemar; Bezerra Filho, B (s.d.)An acute and lethal encephalomyelitis outbreak took place in Fortaleza, State of Ceará, Brazil, from November 11 to 24 of 1960, in people bitten by dogs, who had been submitted, almost immediately after the bite, to a ...
Pan American Health Organization; Family, Health Promotion and Life Course (FPL) (Washington, D.C., PAHO, 2009-05)The present Regional Plan for Pandemic Influenza Vaccination falls under the activities of PAHO’s technical cooperation with Member States of the Region to address a possible pandemic. One of the best prevention method is ...