Desarrollo de métodos inmunológicos para regular la fecundidad
A new approach to fertility regulation is the development of vaccines directed against human substances required for reproduction. Potential candidates for immunological interference include reproductive hormones, ovum and sperm antigens, and antigens derived from embryonic or fetal tissue. Several vaccines targeted at the beta chain of the human chorionic gonadotrophin molecule have reached the clinical trial state in Australia, Finland, India and Sweden, and the preliminary results are very encouraging. A prototype vaccine using the beta subunit of ovine luteinizing hormone seems effective in female primates. Contradictory effects on spermatogenisis in male primates have been observed by different researchers using follicle-stimulating hormone as an antigen. Both this and gonadotrophin-releasing hormone require further basic research. Immunological interference could also be aimed at a sperm production or maturation, or at sperm-ovum interaction in the female reproductive tract. The best characterized sperm antigen to date is LDH-C4, an isoenzime of lactic dehydrogenase. The identification of new sperm antigens is being aided by monoclonal antibody techniques. Another approach is to detect, and then mimic, the antisperm antibodies found in women and men with immunologically mediated infertility. Research on ovum antigens is focusing on the zona pellucida (ZP); anti-ZP antibodies
Showing items related by title, author, creator and subject.
La inducción de anticuerpos anti-VIAA en bovinos vacunados y revacunados con vacuna inactivada antiaftosa Alonso, A.; Gomes, I.; Bahnemann, H. G. (Rio de Janeiro, OPS, 1988)La presencia de anticuerpos para el antígeno asociado a la infección viral (VIAA) en sueros de bovinos ha sido interpretada como una indicación de que los animales han sido infectados con el virus de la fiebre aftosa o han ...
Mendez L., Maria; Arce E., Miguel; Kruger P., Hever; Sanchez S, Sara (s.d.)A review was undertaken of 5 521 serum samples that had been tested to detect or confirm the presence of different hepatitis A, B, and delta serologic markers. The sources of the samples included a national reference ...
Field application of inactivated oil adjuvanted Foot-and-Mouth disease virus vaccine: vaccination and revaccination of young cattle Augé de Mello, P; Astudillo, V; Campos Garcia, JT; Gomes, I (Rio de Janeiro, PAHO, 1975)[Introduction] This paper describes the results of antibody studies after the vaccination and revaccination of young cattle with oil adjuvanted AEI inactivated FMD virus vaccines. The immune response of a group of these ...