Evaluación de la vacuna combinada attenuvax-viruela en Chile

Abstract

Reactions to combined attenuvax-smallpox vaccine were studied, and were compared with those produced by each type of vaccine separately, in children from one to five years of age, controlled by maternal-child care centers under the National Health Service in Santiago, Chile. Combined freeze-dried and preblended attenuvax-smallpox vaccine and freeze-dried "Dryvax" smallpox vaccine were used. The combined vaccine was jet-injected, while the measles vaccine was administered in the form of subcutaneous injections, and the smallpox vaccine by the multipuncture technique

The new preblended and combined attenuvax-smallpox vaccine administered by jet injection produces general clinical reactions similar to or milder than those caused by each vaccine when administered separately

"Takes" were recorded in 96.9 per cent of children inoculated with the combined vaccine, which is an excellent result

To judge from the rise in titers in serological tests counts for both viruses in the cases inoculated, there was no evidence of interference between antigens. The conversion rate for each virus closely resembled that obtained when each vaccine was administered separately, and the geometric mean of the hemoagglutination inhibition titers was also very similar for the combined vaccine and for each vaccine administered separately

Revaccination against smallpox in children inoculated two months earlier with the ... (AU)