Aislamiento e identificación de virus de fiebre aftosa procedente de vesículas en la epidermis de un ser humano

Abstract

1. A cytopathogenic agent for bovine kidney cells isolated from hand vesicles of a human being

2. This agent is pathogenic for bovine kidney cells in vitro, guinea pigs and suckling mice

3. This agent belongs immunologically to the "O" type foot and mouth disease virus

Discussion

In spite of the fact that the patient has been working for over 10 years with foot and mouth disease viral materials, she never presented before similar symptoms. A search for heterologous antibodies produced by inapparent or subclinical infections was made. Neither the acute nor the convalescent sera, when diluted 1:8, revealed the presence of antibodies against A and C type foot and mouth viruses

This brief paper shows the possible existence in nature of some peculiar foot and mouth virus strains, which, in some special circumstances, could infect man

Conclusions

The fluid from a hand vesicle of a human produced destruction in bovine kidney cultural cells. In this way a cytopathogenic agent has been isolated in vitro. The specific inhibition of cellular destruction by this agent in the presence of "O" type hyperimmune guinea pig serum proves that this agent belongs immunologically to the "O" type foot and mouth disease virus

It is the first time that a foot and mouth disease virus from a human has been isolated in bovine kidney cells cultured in vitro(AU)

Este trabajo se publica simultáneamente en el Canadian Veterinary Journal