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dc.contributor.authorCastillo, Juanes
dc.contributor.authorArteaga, Griseldaes
dc.contributor.authorMendoza, Yaxelises
dc.contributor.authorMartínez, Alexander Aes
dc.contributor.authorSamaniego, Rigobertoes
dc.contributor.authorEstripeaut, Doraes
dc.contributor.authorPage, Kathleen Res
dc.contributor.authorSmith, Rebecca Ees
dc.contributor.authorSosa, Nestores
dc.contributor.authorPascale, Juan Mes
dc.date.accessioned2015-08-25T14:55:32Z
dc.date.available2015-08-25T14:55:32Z
dc.date.issued2011es
dc.identifier.citationCastillo, Juan,Arteaga, Griselda,Mendoza, Yaxelis,Martínez, Alexander A,Samaniego, Rigoberto,Estripeaut, Dora,Page, Kathleen R,Smith, Rebecca E,Sosa, Nestor,Pascale, Juan M (2011) HIV transmitted drug resistance in adult and pediatric populations in Panama. Rev Panam Salud Publica;30(6),dec. 2011. Retrieved from http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892011001200025&lng=es&nrm=iso&tlng=enes
dc.identifier.urihttp://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892011001200025&lng=es&nrm=iso&tlng=enes
dc.identifier.urihttp://iris.paho.org/xmlui/handle/123456789/9400
dc.format.extenttabes
dc.relation.ispartofseriesRev Panam Salud Publica;30(6),dec. 2011es
dc.subjectHIV-1es
dc.subjectDrug Resistancees
dc.subjectInfectious Disease Transmission, Verticales
dc.subjectProtease Inhibitorses
dc.subjectAntiretroviral Therapy, Highly Activees
dc.subjectPanamaes
dc.subjectVIH-1es
dc.subjectresistencia a medicamentoses
dc.subjecttransmisión vertical de enfermedad infecciosaes
dc.subjectinhibidores de proteasaes
dc.subjectterapia antirretroviral altamente activaes
dc.subjectPanamáes
dc.subjectFármacos Anti-HIVes
dc.subjectFarmacorresistência Virales
dc.subjectHIV-1es
dc.subjectFármacos Anti-HIVes
dc.subjectFarmacorresistência Virales
dc.subjectGenes Poles
dc.subjectGenótipoes
dc.subjectInfecções por HIVes
dc.subjectInfecções por HIVes
dc.subjectInfecções por HIVes
dc.subjectInfecções por HIVes
dc.subjectProtease de HIVes
dc.subjectInibidores da Protease HIVes
dc.subjectInibidores da Protease HIVes
dc.subjectTranscriptase Reversa do HIVes
dc.subjectHIV-1es
dc.subjectHIV-1es
dc.subjectTransmissão Vertical de Doença Infecciosaes
dc.subjectPanamáes
dc.subjectComplicações Infecciosas na Gravidezes
dc.subjectPrevalênciaes
dc.subjectInibidores de Transcriptase Reversaes
dc.subjectInibidores de Transcriptase Reversaes
dc.titleHIV transmitted drug resistance in adult and pediatric populations in Panamaes
dc.typeJournal Articlees
dc.description.notesObjetivo. Investigar la prevalencia de farmacorresistencia transmitida del VIH en adultos en Panamá mediante un estudio del umbral modificado de la Organización Mundial de la Salud (OMS) e investigar las tasas de resistencia inicial en lactantesseropositivos para el VIH en Panamá.Métodos. En el Instituto Conmemorativo Gorgas, en 47 adultos seropositivos al VIH se efectuó la genotipificación de las mutaciones asociadas con la farmacorresistencia transmitida en los genes de la transcriptasa inversa y la proteasa del VIH-1, según las directrices del estudio umbral de la OMS, modificadas para incluir a las personas ≤ 26 años de edad. Las tasas de prevalencia de las mutaciones farmacorresistentes contra tres clases de fármacos antirretroviral inhibidores de la transcriptasa inversaanálogos de nucleósidos, inhibidores de la transcriptasa inversa no análogos de nucleósidos e inhibidores de la proteasa se clasificaron en bajas ( 15,0%). También se llevó a cabo genotipificación y se calcularonlas tasas de prevalencia de las mutaciones causantes de farmacorresistencia en 25 lactantes.Resultados. En los adultos de Panamá la farmacorresistencia transmitida fue moderada: 6 de 47 adultos seropositivos para el VIH presentaron una o más mutacionesasociadas con farmacorresistencia transmitida. Las mutaciones farmacorresitentes de transmisión horizontal fueron moderadas para los inhibidores de la transcriptasainversa análogos de nucleósidos y los inhibidores de la transcriptasa inversa no análogos de nucleósidos, y bajas para los inhibidores de la proteasa. En Panamá la transmisiónvertical del VIH ha disminuido en el período 2002 2007, pero la prevalenciade la farmacorresistencia del VIH transmitida por vía vertical es moderada (12,0%) y está surgiendo como un problema debido a la cobertura antirretroviral incompletadurante el embarazo...(AU)es
dc.description.notesObjective. To investigate the prevalence of transmitted drug-resistant HIV among adults in Panama by using a modified World Health Organization Threshold Survey (WHO-TS) and to investigate rates of initial resistance among HIV-positive infants in Panama.Methods. At the Gorgas Memorial Institute, 47 HIV-positive adults were genotyped for mutations associated with transmitted drug resistance (TDR) in the reverse transcriptase andprotease genes of HIV-1, according to WHO-TS guidelines, modified to include patients ≤ 26 years old. Prevalence rates for drug-resistance mutations against three classes of antiretroviraldrugs nucleoside analog reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors were calculated as low ( 15.0%). Twenty-five infant patients were also genotyped and prevalence rates for drug-resistance mutations were calculated. Results. TDR among Panamanian adults was moderate: 6 of 47 HIV-positive adultsshowed one or more mutations associated with TDR. Horizontal TDR mutations were moderate for NRTIs and NNRTIs and low for protease inhibitors. Vertical transmission of HIV inPanama has decreased for 2002 2007, but vertical HIV TDR prevalence is moderate (12.0%) and is emerging as a problem due to incomplete antiretroviral coverage in pregnancy. Conclusions. The prevalence of HIV TDR indicated by this study, combined with knownrates of HIV infection in Panama, suggests more extensive surveys are needed to identify risk factors associated with transmission of HIV drug resistance. Specific WHO-TS guidelines for monitoring vertical transmission of drug-resistant HIV should be established.(AU)es


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