Culture and drug susceptibility testing among previously treated tuberculosis patients in the Dominican Republic, 2014
Date
2016Author
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Multidrug-resistant tuberculosis (MDR-TB) is a major public health concern that threatens global progress toward effective TB control. The risk of MDR-TB is increased in patients who have received previous TB treatment. This article describes the performance of culture and drug susceptibility testing (DST) in patients registered as previously treated TB patients in the Dominican Republic in 2014, based on operational research that followed a retrospective cohort design and used routine program data. Under the current system of TB culturing and DST, the majority of patients with previously treated TB do not undergo DST, and those who do often experience considerable delay in obtaining their results. The lack of DST and delay in receiving DST results leads to underestimation of the number of MDR-TB cases and hinders the timely initiation of MDR-TB treatment. La tuberculosis multirresistente (MR) constituye un importante problema de salud pública que amenaza el progreso hacia un control eficaz de la tuberculosis en el mundo. Los pacientes con antecedentes de tratamiento antituberculoso presentan un mayor riesgo de padecer tuberculosis MR. En la presente investigación operativa se describe el rendimiento diagnóstico del cultivo y el antibiograma (prueba de sensibilidad a drogas) en los pacientes registrados como casos de tuberculosis previamente tratados en la República Dominicana en el 2014, mediante un estudio retrospectivo de cohortes, a partir de los datos recolectados rutinariamente por el programa. En el sistema actual, el cultivo y el antibiograma no se practican en la mayoría de los pacientes previamente tratados y, cuando se realizan, el retraso en la obtención de los resultados suele ser considerable. La falta de antibiograma y la demora en la recepción de sus resultados ocasionan una subestimación del número de casos de tuberculosis MR y obstaculizan el inicio oportuno del tratamiento de este tipo de tuberculosis.
Translated title
Cultivo y antibiograma en pacientes previamente tratados por tuberculosis en la República Dominicana en el 2014
Subject
Tuberculosis; Tuberculosis, Multidrug-Resistant; Culture Techniques; Microbial Sensitivity Tests; Cohort Studies; Operations Research; Dominican Republic; Tuberculosis Resistente a Múltiples Medicamentos; Técnicas de Cultivo; Pruebas de Sensibilidad Microbiana; Estudios de Cohortes; Investigación Operativa; República Dominicana
Citation
Romero Mercado KJ, Marcelino B, Rodríguez M, Verdonck K, Khogali M, Bissell K. Culture and drug susceptibility testing among previously treated tuberculosis patients in the Dominican Republic, 2014. Rev Panam Salud Publica. 2016;39(1):60–4.
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