Estabilidad de la vacuna antirrábica de cerebro de ratón lactante almacenada a distintas temperaturas
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Considering that every year some 300 people die of rabies in Latin America and the Caribbean, it is important for the Region to have rabies vaccines that are potent, innocuous, stable, and inexpensive. The type of rabies vaccine most widely used for both human and animal purposes at present is suckling mouse brain (SMB) vaccine. To demonstrate the stability of SMB vaccine at different temperatures, test lots of liquid and lyophilized SMB vaccine were prepared for human and canine use. Samples were then stored at 4oC, 25oC, and 37oC; and their antigenic potency was checked periodically by the NIH test. The average antigenic potency of six test lots of liquid SMB vaccine prepared for human use declined by some 52.3 percent, from an initial average level of 0.8, when stored at 4oC over 15 months. However, all the lots met the minimum potency requirement established by the NIH test at the end of 15 months at 4oC. All six also retained acceptable potency for 30 days when stored at 37oC. Similar patterns were exhibited by lots of liquid vaccine prepared for canine and bovine use
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Solucoes de sorbitol-gelatina e de acido glutamico-lactose na estabilizacao de preparacoes referencia do virus do sarampo Rizzo, Eda de; Nunez Tenorio, Elisabeth Christina; Mendes, Inacio Franca; Liauw Woe Fang, Francisco; Pral, Michel Marie; Sayoko Takata, Celia; Miyaki, Cosue; Frazatti Gallina, Neuza Maria; Nakahata Tuchiya, Hiroko; Kikue Akimura, Olga (1988)The study described in this article was carried out for the purpose of evaluating the protective effects of two stabilizing solutions- sorbitol-gelatin and glutamic acid-lactose- on freeze-dried measles virus (Schwartz ...
Díaz, Ana Maria O. de; Dellepiane, Nora; Palomo, Luis F (1989)Suckling mouse brain (SMB) rabies vaccine is the preparation most widely used in the countries of Latin America and the Caribbean
Soriano Lleras, Andrés (1946)The National Institutes of Health of the Latin American countries, besides control, are also responsible for the preparation and distribution of biological products for health campaigns. In fact, in some of them, production ...